Venlafaxine Impurity 75 CAS 2450358-09-3 (free base)
| CAS No. | 2450358-09-3 (free base) |
| Molecular Formula | C15H21NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Venlafaxine Impurity 75 is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 267.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Venlafaxine Impurity 75 (CAS 2450358-09-3 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C15H21NOHCl and a molecular weight of 267.80 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21NO HCl |
| Molecular Weight | 267.80 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Venlafaxine Standards
- Venlafaxine Impurity 58 (CAS 1000377-27-4)
- Venlafaxine Impurity 31 (CAS 1020719-35-0)
- Venlafaxine Impurity 15 (CAS 1021933-95-8)
- Venlafaxine Impurity 33 (CAS 1062607-49-1)
- Venlafaxine Impurity 36 (CAS 1062609-99-7)
- Venlafaxine EP Impurity G (CAS 1076199-92-2)
- Venlafaxine N-Oxide (CAS 1094598-37-4)
- Venlafaxine Impurity 18 (CAS 1168135-16-7)
Recommended Standards
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- 6-Methyl-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carbonitrile (CAS 911388-96-0)
- (2E)-3-(2,3-Dimethoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one (CAS 39060-03-2)
- 1,5,6-Trichloroacenaphthene (CAS 84944-90-1)
- 3-Bromo-4-methyl-4H-1,2,4-triazole (CAS 16681-73-5)
- N1-(tetrahydro-2H-pyran-3-yl)benzene-1,2-diamine (CAS 1393176-37-8)
- 3,6-Dichloro-2-(difluoromethoxy)benzyl chloride (CAS 1806328-40-4)
- Acetyl decapeptide-3 (CAS 935288-50-9)
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